Central mechanisms of pathological pain

被引:643
作者
Kuner, Rohini [1 ]
机构
[1] Univ Heidelberg, Inst Pharmacol, D-6900 Heidelberg, Germany
关键词
PERIPHERAL-NERVE INJURY; DORSAL-HORN NEURONS; CENTRAL SEROTONERGIC NEURONS; MICROGLIAL CATHEPSIN-S; AMPA RECEPTOR SUBUNITS; SPINAL-CORD NEURONS; NEUROPATHIC PAIN; INFLAMMATORY PAIN; GABAERGIC INHIBITION; SYNAPTIC PLASTICITY;
D O I
10.1038/nm.2231
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Chronic pain is a major challenge to clinical practice and basic science. The peripheral and central neural networks that mediate nociception show extensive plasticity in pathological disease states. Disease- induced plasticity can occur at both structural and functional levels and is manifest as changes in individual molecules, synapses, cellular function and network activity. Recent work has yielded a better understanding of communication within the neural matrix of physiological pain and has also brought important advances in concepts of injury- induced hyperalgesia and tactile allodynia and how these might contribute to the complex, multidimensional state of chronic pain. This review focuses on the molecular determinants of network plasticity in the central nervous system (CNS) and discusses their relevance to the development of new therapeutic approaches.
引用
收藏
页码:1258 / 1266
页数:9
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