Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

被引：316

作者：

Braak, H

Braak, E

机构：

[1] Department of Anatomy, J. W. Goethe University, D-60590 Frankfurt/Main

来源：

ACTA NEUROPATHOLOGICA | 1996年 / 92卷 / 02期

关键词：

oligodendrocytes; myelination; Alzheimer's disease; neurofibrillary tangles; neuropil threads;

D O I：

10.1007/s004010050508

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.

引用

页码：197 / 201

页数：5

共 23 条

[1]

[Anonymous], 1994, NEURODEGENER DIS

[2]

A SEQUENCE OF CYTOSKELETON CHANGES RELATED TO THE FORMATION OF NEUROFIBRILLARY TANGLES AND NEUROPIL THREADS [J].