Targeting telomeres and telomerase

被引：508

作者：

De Cian, Anne ^{[1
,2
]}

Lacroix, Laurent ^{[1
,2
]}

Douarre, Celine ^{[3
]}

Temime-Smaali, Nassima ^{[3
]}

Trentesaux, Chantal ^{[3
]}

Riou, Jean-Francois ^{[3
]}

Mergny, Jean-Louis ^{[1
,2
]}

机构：

[1] CNRS, UMR5153, Museum Natl Hist Nat USM503, Dept Regulat Dev & Diversite Mol,Lab Regulat & Dy, F-75231 Paris 05, France

[2] INSERM, U565, F-75231 Paris 05, France

[3] Univ Reims, Lab Oncopharmacol, UFR Pharm, F-51096 Reims, France

来源：

BIOCHIMIE | 2008年 / 90卷 / 01期

关键词：

telomere; telomerase; quadruplex; shelterin; anticancer agents;

D O I：

10.1016/j.biochi.2007.07.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：131 / 155

页数：25

共 336 条

[1] Rad54 is dispensable for the ALT pathway [J].

Akiyama, Koichi ;

Yusa, Kosuke ;

Hashimoto, Hideharu ;

Poonepalli, Anuradha ;

Prakash Hande, Manoor ;

Kakazu, Naoki ;

Takeda, Junji ;

Tachibana, Makoto ;

Shinkai, Yoichi .

GENES TO CELLS, 2006, 11 (11) :1305-1315

[2]

Akiyama M, 2003, CANCER RES, V63, P6187

[3] Interaction of an acridine dimer with DNA quadruplex structures [J].

Alberti, P ;

Ren, JS ;

Teulade-Fichou, MP ;

Guittat, L ;

Riou, JF ;

Chaires, JB ;

Hélène, C ;

Vigneron, JP ;

Lehn, JM ;

Mergny, JL .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2001, 19 (03) :505-513

[4] Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase [J].

Alberti, P ;

Schmitt, P ;

Nguyen, CH ;

Rivalle, C ;

Hoarau, M ;

Grierson, DS ;

Mergny, JL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (07) :1071-1074

[5] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution [J].

Ambrus, Attila ;

Chen, Ding ;

Dai, Jixun ;

Bialis, Tiffanie ;

Jones, Roger A. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2723-2735

[6] A topological mechanism for TRF2-enhanced strand invasion [J].

Amiard, Simon ;

Doudeau, Michel ;

Pinte, Sebastien ;

Poulet, Anais ;

Lenain, Christelle ;

Faivre-Moskalenko, Cendrine ;

Angelov, Dimitar ;

Hug, Nele ;

Vindigni, Alessandro ;

Bouvet, Philippe ;

Paoletti, Jacques ;

Gilson, Eric ;

Giraud-Panis, Marie-Josephe .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (02) :147-154

[7]

AOKI H, 2007, IN PRESS FASEB J, DOI DOI 10.1096/FJ.1006-6941COM

[8] T-oligos augment UV-induced protective responses in human skin [J].

Arad, Simin ;

Konnikov, Nellie ;

Goukassian, David A. ;

Gilchrest, Barbara A. .

FASEB JOURNAL, 2006, 20 (11) :1895-+

[9]

Asai A, 2003, CANCER RES, V63, P3931

[10] Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters [J].

Atkinson, SP ;

Hoare, SF ;

Glasspool, RM ;

Keith, WN .

CANCER RESEARCH, 2005, 65 (17) :7585-7590

← 1 2 3 4 5 6 7 8 9 10 →