Alternative splicing and evolution

被引：113

作者：

Boue, S ^{[1
]}

Letunic, I ^{[1
]}

Bork, P ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

BIOESSAYS | 2003年 / 25卷 / 11期

关键词：

GENE STRUCTURE; EXON DUPLICATION; MOUSE; GENOME; CONSERVATION; PREDICTION; FREQUENCY; SEQUENCES; ESTS;

D O I：

10.1002/bies.10371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Alternative splicing is a critical post-transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms.((1)) It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint. (C) 2003 Wiley Periodicals, Inc.

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收藏

页码：1031 / 1034

页数：4

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