Epigenetic reprogramming: Enforcer or enabler of developmental fate?

被引：11

作者：

Combes, Alexander N. ^{[1
]}

Whitelaw, Emma ^{[1
,2
]}

机构：

[1] Queensland Inst Med Res, Div Genet & Populat Hlth, Brisbane, Qld 4006, Australia

[2] Griffith Univ, Griffith Med Res Coll, Brisbane, Qld 4111, Australia

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2010年 / 52卷 / 06期

基金：

英国医学研究理事会;

关键词：

development; DNA methylation; epigenetics; histone modification; reprogramming; PRIMORDIAL GERM-CELLS; DE-NOVO METHYLATION; DNA METHYLATION; TRANSCRIPTIONAL ACTIVATION; GENE-EXPRESSION; STEM-CELLS; MOUSE; CHROMATIN; METHYLTRANSFERASE; TROPHECTODERM;

D O I：

10.1111/j.1440-169X.2010.01185.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

A single fertilized egg is programmed to differentiate into a multitude of distinct cell types that comprise a multicellular organism. Epigenetic mechanisms such as DNA methylation and histone modifications are intricately involved in regulating developmental potential and cellular identity by establishing permissive or repressive chromatin states that are mitotically heritable. Here, we review the dynamics of major epigenetic marks during early mammalian development, and explore the question of whether DNA methylation and chromatin modifications enable or enforce changes that lead to the first cell fate decision.

引用

页码：483 / 491

页数：9

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