HaploPainter:: a tool for drawing pedigrees with complex haplotypes

被引：233

作者：

Thiele, H ^{[1
]}

Nürnberg, P

机构：

[1] Max Delbruck Ctr Mol Med, Gene Mapping Ctr, Berlin, Germany

[2] Charite Univ Med Berlin, Inst Med Genet, Berlin, Germany

[3] Univ Cologne, Cologne Ctr Genom, D-5000 Cologne, Germany

来源：

BIOINFORMATICS | 2005年 / 21卷 / 08期

关键词：

D O I：

10.1093/bioinformatics/bth488

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

HaploPainter is a user-friendly pedigree-drawing application with special features for easy visualization of complex haplotype information. It has been developed to facilitate gene mapping in Mendelian diseases in terms of fast and reliable definition of the smallest critical interval harbouring the underlying gene defect. HaploPainter is written in Perl and may be used for visualization of haplotypes calculated by any of the common linkage programs. With special features like haplotype compression or the ability of marker section cut-out it particularly addresses the requirements for viewing large haplotypes as obtained by using for genome scans high-density marker panels of many thousands of single nucleotide polymorphisms (SNPs).

引用

页码：1730 / 1732

页数：3

共 13 条

[1] Merlin-rapid analysis of dense genetic maps using sparse gene flow trees [J].

Abecasis, GR ;

Cherny, SS ;

Cookson, WO ;

Cardon, LR .

NATURE GENETICS, 2002, 30 (01) :97-101

[2] CoPE: a collaborative pedigree drawing environment [J].

Brun-Samarcq, L ;

Gallina, S ;

Philippi, A ;

Demenais, F ;

Vaysseix, G ;

Barillot, E .

BIOINFORMATICS, 1999, 15 (04) :345-346

[3] A VISUAL INTERFACE TO COMPUTER-PROGRAMS FOR LINKAGE ANALYSIS [J].

CHAPMAN, CJ .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1990, 36 (02) :155-160

[4] Pelican: pedigree editor for linkage computer analysis [J].

Dudbridge, F ;

Carver, T ;

Williams, GW .

BIOINFORMATICS, 2004, 20 (14) :2327-2328

[5] Allegro, a new computer program for multipoint linkage analysis [J].

Gudbjartsson, DF ;

Jonasson, K ;

Frigge, ML ;

Kong, A .

NATURE GENETICS, 2000, 25 (01) :12-13

[6] Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy [J].

Janecke, AR ;

Thompson, DA ;

Utermann, G ;

Becker, C ;

Hübner, CA ;

Schmid, E ;

McHenry, CL ;

Nair, AR ;

Rüschendorf, F ;

Heckenlively, J ;

Wissinger, B ;

Nurnberg, P ;

Gal, A .

NATURE GENETICS, 2004, 36 (08) :850-854

[7] Missense mutations of ACTA1 cause dominant congenital myopathy with cores [J].

Kaindl, AM ;

Rüschendorf, F ;

Krause, S ;

Goebel, HH ;

Koehler, K ;

Becker, C ;

Pongratz, D ;

Müller-Höcker, J ;

Nürnberg, P ;

Stoltenburg-Didinger, G ;

Lochmüller, H ;

Huebner, A .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (11) :842-848

[8]

Kruglyak L, 1996, AM J HUM GENET, V58, P1347

[9]

MAMELKA PM, 1990, 1 PGL SW FDN BIOM RE

[10]

RUSCHENDORF F, 2005, BIOINFORMATICS 0112

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