Cardenolide biosynthesis in foxglove

被引：57

作者：

Kreis, W ^{[1
]}

Hensel, A ^{[1
]}

Stuhlemmer, U ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Bot & Pharmazeut Biol, D-91058 Erlangen, Germany

来源：

PLANTA MEDICA | 1998年 / 64卷 / 06期

关键词：

biosynthesis; cardenolides; cardiac glycosides; glycosidase; glycosyl transferase; enzymes; feeding experiments; Digitalis; oxido-reductases; secondary metabolism; Scrophulariaceae; tracer studies;

D O I：

10.1055/s-2006-957500

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The article reviews the state of knowledge on the biosynthesis of cardenolides in the genus Digitalis. It summarizes studies with labelled and unlabelled precursors leading to the formulation of the putative cardenolide pathway. Alternative pathways of cardenolide biosynthesis are discussed as well. Special emphasis is laid on enzymes involved in either pregnane metabolism or the modification of cardenolides. About 20 enzymes which are probably involved in cardenolide formation have been described "downstream" of cholesterol, including various reductases, oxido-reductases, glycosyl transferases and glycosidases as well as acyl transferases, acyl esterases and P450 enzymes. Evidence is accumulating that cardenolides are not assembled on one straight conveyor belt but instead are formed via a complex multidimensional metabolic grid. For example "fucose-type" cardenolides and "digitoxose-type" cardenolides seem to form via different biosynthetic branches and the "norcholanic acid pathway" identified recently seems to be operative only in the formation of fucose-type cardenolides.

引用

页码：491 / 499

页数：9

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