Zinc-rich afferents to the rat neocortex:: projections to the visual cortex traced with intracerebral selenite injections

被引:35
作者
Casanovas-Aguilar, C
Reblet, C
Pérez-Clausell, J
Bueno-López, JL
机构
[1] Univ Barcelona, Fac Biol, Dept Biol Cellular Anim & Vegetal, ES-08071 Barcelona, Spain
[2] Univ Basque Country, Dept Neurociencias, ES-48940 Leioa, Spain
关键词
claustrum; cortico-cortical connections; frontal cortex; orbital cortex; pyramidal neurons; retrograde transport; Timm method;
D O I
10.1016/S0891-0618(98)00035-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Infusion of sodium selenite to the occipital cortex of the rat was used for the specific tracing of zinc-rich pathways. Large numbers of labeled somata were found ipsilaterally in the visual, orbital and frontal cortices, and contralaterally in homotopic and heterotopic visual areas. Labeled neurons were also found ipsilaterally in the retrosplenial, parietal, sensory-motor, temporal and perirhinal cortex. In contrast to the cortico-cortical connections, ascending afferents to the visual cortex were not zinc-rich except for a few labeled neurons in the claustrum. Additional injections showed reciprocal zinc-rich connections between the visual cortex and the orbital and frontal cortices. The latter cortices also received ascending zinc-rich afferents from the claustrum. Selenite injections revealed the layered distribution and the morphology of these labeled neurons in the neocortex. Zinc-rich neurons were found in layers II-III, V and VI. However, none was found in layer IV. Zinc-rich somata appeared as pyramidal and inverted neurons. The contrasting chemical properties of cortical and subcortical visual afferents may account for the functional differences between these systems. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:97 / 109
页数:13
相关论文
共 62 条
[1]  
Amaral David G., 1995, P443
[2]   RELEASE OF ENDOGENOUS ZN-2+ FROM BRAIN-TISSUE DURING ACTIVITY [J].
ASSAF, SY ;
CHUNG, SH .
NATURE, 1984, 308 (5961) :734-736
[3]   ENRICHMENT OF GLUTAMATE IN ZINC-CONTAINING TERMINALS OF THE CAT VISUAL-CORTEX [J].
BEAULIEU, C ;
DYCK, R ;
CYNADER, M .
NEUROREPORT, 1992, 3 (10) :861-864
[4]   GIANT SYNAPTIC POTENTIALS IN IMMATURE RAT CA3 HIPPOCAMPAL-NEURONS [J].
BENARI, Y ;
CHERUBINI, E ;
CORRADETTI, R ;
GAIARSA, JL .
JOURNAL OF PHYSIOLOGY-LONDON, 1989, 416 :303-325
[5]   TARGETS AND LAMINAR DISTRIBUTION OF PROJECTION NEURONS WITH INVERTED MORPHOLOGY IN RABBIT CORTEX [J].
BUENOLOPEZ, JL ;
REBLET, C ;
LOPEZMEDINA, A ;
GOMEZURQUIJO, SM ;
GRANDES, P ;
GONDRA, J ;
HENNEQUET, L .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1991, 3 (05) :415-430
[6]   RAPID INDUCTION OF ALZHEIMER A-BETA AMYLOID FORMATION BY ZINC [J].
BUSH, AI ;
PETTINGELL, WH ;
MULTHAUP, G ;
PARADIS, MD ;
VONSATTEL, JP ;
GUSELLA, JF ;
BEYREUTHER, K ;
MASTERS, CL ;
TANZI, RE .
SCIENCE, 1994, 265 (5177) :1464-1467
[7]   THE RAT CLAUSTRUM - AFFERENT AND EFFERENT CONNECTIONS WITH VISUAL-CORTEX [J].
CAREY, RG ;
NEAL, TL .
BRAIN RESEARCH, 1985, 329 (1-2) :185-193
[8]  
CASANOVASAGUILA.C, 1995, EUR J NEUROSCI, V8, P32
[9]   CALLOSAL NEURONS GIVE RISE TO ZINC-RICH BOUTONS IN THE RAT VISUAL-CORTEX [J].
CASANOVASAGUILAR, C ;
CHRISTENSEN, MK ;
REBLET, C ;
MARTINEZGARCIA, F ;
PEREZCLAUSELL, J ;
BUENOLOPEZ, JL .
NEUROREPORT, 1995, 6 (03) :497-500
[10]   RETROGRADE TRACING OF ZINC-CONTAINING NEURONS BY SELENIDE IONS - A SURVEY OF 7 SELENIUM-COMPOUNDS [J].
CHRISTENSEN, MK ;
FREDERICKSON, CJ ;
DANSCHER, G .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1992, 40 (04) :575-579