Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis

被引:61
作者
Thompson-Fawcett, MW [1 ]
Marcus, VA
Redston, M
Cohen, Z
McLeod, RS
机构
[1] Steve Atanas Stavro Familial Colon Canc Registry, Toronto, ON, Canada
[2] Univ Toronto, Mt Sinai Hosp, Dept Surg, Toronto, ON M5G 1X5, Canada
[3] Univ Toronto, Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada
关键词
familial adenomatous polyposis; ileal pouch; adenomas;
D O I
10.1007/BF02234731
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PURPOSE: The aim of this study was to establish the prevalence of adenomatous polyps in the ileal pouch of patients with familial adenomatous polyposis. METHOD: Forty-three patients who had an ileal pouch for familial adenomatous polyposis were invited to have a careful endoscopic examination of their pouch, including dye spraying. The number of polyps was recorded, and up to ten were biopsied. In addition, four random biopsy specimens were taken from the proximal and four from the distal pouch. RESULTS: Thirty-three patients with a median age of 36 (range, 14-63) years who had a pouch (5 Kock and 28 pelvic) for a median of 7 (range, 1-19) years accepted the invitation. Twenty-one patients (64 percent) had endoscopically identified polyps, the number of polyps ranging from 1 to 100 (median, 10) and varying in size from 1 to 3 mm. Fourteen patients (42 percent) had adenomatous polyps and 4 of these also had microadenomas on random biopsies. Nine of the 14 patients with adenomas also had lymphoid polyps. Seven patients had lymphoid polyps only and two of these patients had a microadenoma on random biopsy. Four of 12 patients with no visible polyps had microadenomas in their random biopsies. The presence of adenomatous polyps (Pearson's correlation; P < 0.01) increased with the age of the pouch. In total, 20 of 33 (60 percent) patients had adenomas and or microadenomas. CONCLUSION: Adenomatous polyps occur frequently in ileal pouches. These findings are of concern, and therefore, regular surveillance seems warranted until the natural history of these adenomatous polyps is determined.
引用
收藏
页码:347 / 353
页数:7
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