Experimental demonstration of the possibility to perform shear-driven chromatographic separations in micro-channels

被引：28

作者：

Desmet, G ^{[1
]}

Vervoort, N ^{[1
]}

Clicq, D ^{[1
]}

Baron, GV ^{[1
]}

机构：

[1] Free Univ Brussels, Dept Chem Engn, B-1050 Brussels, Belgium

来源：

JOURNAL OF CHROMATOGRAPHY A | 2001年 / 924卷 / 1-2期

关键词：

shear-driven chromatography; instrumentation; dyes;

D O I：

10.1016/S0021-9673(01)00773-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The possibility to perform shear-driven chromatographic separations in micro-channels is demonstrated, using a novel laser-jet printed microfluidic channel system. The obtained theoretical plate numbers are in fair agreement with the theoretical calculations. Theoretical extrapolations of the separation speeds and detection limits which can be achieved when further miniaturizing the current system are presented as well. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：111 / 122

页数：12

共 19 条

[1] BOOGAERTS S, 2000, THESIS VRIJE U BRUSS
[2] On the possibility of shear-driven chromatography: a theoretical performance analysis
Desmet, G
Baron, GV
[J]. JOURNAL OF CHROMATOGRAPHY A, 1999, 855 (01) : 57 - 70
[3] The possibility of generating high-speed shear-driven flows and their potential application in liquid chromatography
Desmet, G
Baron, GV
[J]. ANALYTICAL CHEMISTRY, 2000, 72 (09) : 2160 - 2165
[4] Dittmann MM, 1995, LC GC-MAG SEP SCI, V13, P800
[5] Electroosmosis- and pressure-driven chromatography in chips using continuous beds
Ericson, C
Holm, J
Ericson, T
Hjertén, S
[J]. ANALYTICAL CHEMISTRY, 2000, 72 (01) : 81 - 87
[6] Lab-on-a-chip: A revolution in biological and medical sciences.
Figeys, D
Pinto, D
[J]. ANALYTICAL CHEMISTRY, 2000, 72 (09) : 330A - 335A
[7] CONVENTIONAL PACKED-COLUMNS VS PACKED OR OPEN TUBULAR MICRO-COLUMNS IN LIQUID-CHROMATOGRAPHY
GUIOCHON, G
[J]. ANALYTICAL CHEMISTRY, 1981, 53 (09) : 1318 - 1325
[8] MICROMACHINING A MINIATURIZED CAPILLARY ELECTROPHORESIS-BASED CHEMICAL-ANALYSIS SYSTEM ON A CHIP
HARRISON, DJ
FLURI, K
SEILER, K
FAN, ZH
EFFENHAUSER, CS
MANZ, A
[J]. SCIENCE, 1993, 261 (5123) : 895 - 897
[9] Fabrication of nanocolumns for liquid chromatography
He, B
Tait, N
Regnier, F
[J]. ANALYTICAL CHEMISTRY, 1998, 70 (18) : 3790 - 3797
[10] KATZ ED, 1985, SCI CHROMATOGRAPHY J, V32, P403

← 1 2 →