The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress

被引：65

作者：

Bahadorani, Sepehr ^{[1
]}

Bahadorani, Peyman ^{[1
]}

Phillips, John P. ^{[2
]}

Hilliker, Arthur J. ^{[1
]}

机构：

[1] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada

[2] Univ Guelph, Dept Mol Biol & Genet, Guelph, ON N1G 2W1, Canada

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2008年 / 63卷 / 01期

关键词：

vitamin supplementation; alpha-tocopherol; Drosophila melanogaster; oxidative stress; normoxia;

D O I：

10.1093/gerona/63.1.35

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Vitamin A (retinol), vitamin C (ascorbic acid), and vitamin E (a-tocopherol) are each thought to play an important role in the aging process. Here, we investigated the effects of these vitamins on Drosophila melanogaster life span under different oxidative stress conditions. Among the vitamins tested, a-tocopherol exhibited the strongest antioxidant activity, extending average and maximum life span for wild-type flies under hyperoxia and for Cu/Zn superoxide dismutase-deficient (SOD1-deficient) flies under normoxia. Retinol supplementation extended life span of SOD1-deficient flies under normoxia, and ascorbic acid supplementation extended life span of wild-type flies under normoxia. However, both retinol and ascorbic acid exhibited a strong prooxidant activity under hyperoxia and shortened life span. Furthermore, ascorbic acid supplementation enhanced the toxic effects of iron, with the iron pool significantly increased in adult whole-body extracts. Taken together, our results document antioxidant and prooxidant contributions of vitamins to D. melanogaster life-span determination under normoxia and under oxidative stress.

引用

页码：35 / 42

页数：8

共 46 条

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