Neuroprotective flavonoids from Flemingia macrophylla

被引：55

作者：

Shiao, YJ ^{[1
]}

Wang, CN ^{[1
]}

Wang, WY ^{[1
]}

Lin, YL ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei, Taiwan

来源：

PLANTA MEDICA | 2005年 / 71卷 / 09期

关键词：

Flemingia macrophylla; Leguminosae; flavonoids; neuroprotection;

D O I：

10.1055/s-2005-871297

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Using an A beta-induced neurotoxicity blocking assay to direct fractionation, three new flavonoids, fleminginin (1), flemingichromone (2), and flemingichalcone (3), and twenty known compounds were isolated from the active fractions of the aerial parts of Flemingia macrophylla. The structures of 1 - 3 were elucidated on the basis of spectroscopic data. When tested for neuroprotective activity, compound 2, osajin (4), 5,7,4 -trihydroxy-6,8-dipre-nylisoflavone (5), 5,7,4'-trihydroxy-6,3-diprenylisoflavone(6), and aureole (7) protected neuronal cells from A beta-induced damage with EC50 values of 31.43 +/- 3.16, 5.01 +/- 1.28,11.25 +/- 1.51, 4.47 +/- 0.65,12.09 +/- 2.55 mu M, respectively.

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收藏

页码：835 / 840

页数：6

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