Serine racemase rs391300 G/A polymorphism influences the therapeutic efficacy of metformin in Chinese patients with diabetes mellitus type 2

被引：22

作者：

Dong, Min ^{[1
]}

Gong, Zhi-Cheng ^{[1
]}

Dai, Xing-Ping ^{[1
]}

Lei, Guang-Hua ^{[2
]}

Lu, Hong-Bin ^{[3
]}

Fan, Lan ^{[1
]}

Qu, Jian ^{[1
]}

Zhou, Hong-Hao ^{[1
]}

Liu, Zhao-Qian ^{[1
]}

机构：

[1] Cent South Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

[2] Cent South Univ, Dept Orthopaed, Changsha 410078, Hunan, Peoples R China

[3] Cent South Univ, Dept Sport Med, Xiangya Hosp, Changsha 410078, Hunan, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2011年 / 38卷 / 12期

基金：

中国国家自然科学基金;

关键词：

diabetes mellitus type 2; genetic polymorphism; metformin; serine racemase; therapeutic efficacy; IONOTROPIC GLUTAMATE RECEPTORS; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; VARIANTS; IDENTIFICATION;

D O I：

10.1111/j.1440-1681.2011.05610.x

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

1. The aim of this study was to investigate the association of the serine racemase (SRR) rs391300 G/A polymorphism with the risk of diabetes mellitus type 2 (T2DM) and to assess the impacts of the polymorphism on the therapeutic efficacy of metformin in Chinese patients.

引用

页码：824 / 829

页数：6

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