Histone acetylases and deacetylases in cell proliferation

被引：585

作者：

Kouzarides, T

机构：

[1] Wellcome CRC Inst, Cambridge CB2 1QR, England

[2] Dept Pathol, Cambridge CB2 1QR, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0959-437X(99)80006-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.

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收藏

页码：40 / 48

页数：9

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