How we manage patients with heparin induced thrombocytopenia

被引：16

作者：

Scully, Marie ^{[1
]}

Gates, Carolyn ^{[2
]}

Neave, Lucy ^{[3
]}

机构：

[1] NIHR UCLH UCL BRC, Univ Coll London Hosp, Cardiometab Programme, Dept Haematol, London, England

[2] Univ Coll London Hosp, London, England

[3] UCLH, Dept Haematol, 60 Whitfield St, London W1T 4EU, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2016年 / 174卷 / 01期

基金：

英国医学研究理事会;

关键词：

heparin induced thrombocytopenia; thrombosis; non heparin anticoagulants; direct acting oral anticoagulants; MOLECULAR-WEIGHT HEPARIN; ARGATROBAN ANTICOAGULATION; ARTERIAL THROMBOSIS; 4TS SCORE; RIVAROXABAN; RISK; THERAPY; HIT; FONDAPARINUX; DIAGNOSIS;

D O I：

10.1111/bjh.14102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin induced thrombocytopenia (HIT) remains a rare, but significant, condition related to mortality and morbidity. The incidence has decreased with reduced use of unfractionated heparin, with the exception of cardiac surgery. Due to the high risk of thrombosis, a switch to a non-heparin anticoagulant is required, until platelet counts normalize. Within the acute setting, argatroban, fondaparinux and direct acting oral anticoagulants (DOACS) are therapeutic options. In patients with HIT-associated thrombosis or who require long-term anticoagulation, warfarin remains the preference, but DOACs are attractive alternatives.

引用

页码：9 / 15

页数：7

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