Isolation and identification of dihydroartemisinic acid from Artemisia annua and its possible role in the biosynthesis of artemisinin

被引：115

作者：

Wallaart, TE ^{[1
]}

van Uden, W ^{[1
]}

Lubberink, HGM ^{[1
]}

Woerdenbag, HJ ^{[1
]}

Pras, N ^{[1
]}

Quax, WJ ^{[1
]}

机构：

[1] Univ Groningen, Dept Pharmaceut Biol, Ctr Pharm, Groningen Inst Drug Studies, NL-9713 AV Groningen, Netherlands

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期

关键词：

D O I：

10.1021/np980370p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Dihydroartemisinic acid (2) was isolated as a natural product from Artemisia annua in a 66% yield, and its structure was confirmed by H-1 and C-13 NMR spectroscopy. Compound 2 could be chemically converted to artemisinin (4) under conditions that may also be present in the living plant. The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.

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页码：430 / 433

页数：4

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