Alkylation of magnesium enamide with alkyl chlorides and fluorides

被引：36

作者：

Hatakeyama, T ^{[1
]}

Ito, S ^{[1
]}

Nakamura, M ^{[1
]}

Nakamura, B ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 41期

关键词：

D O I：

10.1021/ja055306q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A magnesium enamide derived from N-2-(N′,N′-diethylamino)ethyl imine reacts with a primary and secondary alkyl chloride or a primary alkyl fluoride to give an α-alkylated ketone in good to excellent yield after hydrolysis. The reaction takes place with a high level of inversion of stereochemistry at the electrophilic carbon center and will be useful for production of optically active compounds. Copyright © 2005 American Chemical Society.

引用

页码：14192 / 14193

页数：2

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