Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

被引：383

作者：

Chen, HL

Jacobs, E

Schwarzschild, MA

McCullough, ML

Calle, EE

Thun, MJ

Ascherio, A

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Res Triangle Pk, NC USA

[3] Amer Canc Soc, Epidemiol & Surveillance Res Dept, Atlanta, GA 30329 USA

[4] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

ANNALS OF NEUROLOGY | 2005年 / 58卷 / 06期

关键词：

D O I：

10.1002/ana.20682

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated whether nonsteroidal antiinflammatory drug use was associated with a lower risk for Parkinson's disease (PD) in a large cohort of US men and women. PD risk was lower among ibuprofen users than nonusers. Compared with nonusers, the relative risks were 0.73 for users of fewer than 2 tablets/week, 0.72 for 2 to 6.9 tablets/week, and 0.62 for 1 or more tablets/day (p trend=0.03). No association was found between the use of aspirin, other nonsteroidal and inflammatory drugs, or acetaminophen and PD risk. The results suggest that ibuprofen use may delay or prevent the onset of PD.

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页码：963 / 967

页数：5

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