Consistent DNA losses on the short arm of chromosome 1 in a series of malignant gastrointestinal stromal tumors

被引：22

作者：

Derré, J

Lagacé, R

Terrier, P

Sastre, X

Aurias, A

机构：

[1] Inst Curie, INSERM, U509, Sect Rech,Lab Pathol Mol Canc, F-75248 Paris 05, France

[2] Inst Curie, Sect Rech, Dept Pathol, F-75248 Paris, France

[3] CHU Quebec, Hotel Dieu, Dept Pathol, Quebec City, PQ, Canada

[4] Inst Gustave Roussy, Dept Pathol, F-94800 Villejuif, France

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 127卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(00)00409-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fourteen malignant gastrointestinal stromal tumors (GISTs), characterized by immunohistochemistry, were analyzed by comparative genomic hybridization (CGH). The most striking feature was the detection of consistent DNA losses on the short arm of chromosome 1 in these 14 malignant tumors. Additional recurrent imbalances were also found: significant gains, which could he indicative of tumor progression, were frequent on the long arm of chromosome 1, as were losses of DNA copy number detected in chromosomes 13, 14, 15 and 22. (C) 2001 Elsevier science Inc. All rights reserved.

引用

页码：30 / 33

页数：4

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