Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: Implications for treatment

被引:163
作者
Carter-Kent, Christine [1 ]
Zein, Nizar N. [2 ]
Feldstein, Ariel E. [1 ]
机构
[1] Cleveland Clin, Dept Pediat Gastroenterol & Cell Biol, Cleveland, OH 44195 USA
[2] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA
关键词
D O I
10.1111/j.1572-0241.2007.01709.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Nonalcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. NAFLD represents a wide spectrum of conditions ranging from fatty liver, that in general follows a benign nonprogressive clinical course, to nonalcoholic steatohepatitis (NASH), a serious form of NAFLD, that may progress to cirrhosis and end-stage liver disease. The mechanisms responsible for NAFLD development and disease progression remain incompletely understood, but are of great clinical interest as current therapies are limited. Future therapies will be predicted based upon the understanding of its pathogenesis. This review focuses on the growing evidence from both experimental and human studies suggesting a central role of cytokines in the pathogenesis of NAFLD. We review the role of cytokines as key regulators of insulin sensitivity and hepatic lipid overloading, liver injury and inflammation, and fibrosis and cirrhosis, with an emphasis on potential therapeutic implications.
引用
收藏
页码:1036 / 1042
页数:7
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