Intracellular cargo delivery using tat peptide and derivatives

被引：147

作者：

Zhao, M ^{[1
]}

Weissleder, R ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Mol Imaging Res, Charlestown, MA 02129 USA

来源：

MEDICINAL RESEARCH REVIEWS | 2004年 / 24卷 / 01期

关键词：

tat peptide; transduction; cell permeable peptides;

D O I：

10.1002/med.10056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Efficient delivery of therapeutic and diagnostic agents across the plasma membrane is crucial in developing novel therapies. Membrane permeating peptides, in particular HIV-1 tat peptide and its derivatives, have enabled the intracellular delivery of cargos of various sizes and physicochemical properties. This review summarizes the current knowledge of tat-derived cell permeating peptides in the transduction of exogenous molecules/complexes. (C) 2003 Wiley Periodicals, Inc.

引用

页码：1 / 12

页数：12

共 83 条

[1]

Adams PD, 1996, MOL CELL BIOL, V16, P6623

[2] Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: Effects on cellular uptake, binding to target sequences, and biologic actions [J].

Astriab-Fisher, A ;

Sergueev, D ;

Fisher, M ;

Shaw, BR ;

Juliano, RL .

PHARMACEUTICAL RESEARCH, 2002, 19 (06) :744-754

[3] Protein delivery using VP22 [J].

Bennett, RP ;

Dalby, B .

NATURE BIOTECHNOLOGY, 2002, 20 (01) :20-20

[4] SEQUENCE OF CDNA COMPRISING THE HUMAN PUR GENE AND SEQUENCE-SPECIFIC SINGLE-STRANDED-DNA-BINDING PROPERTIES OF THE ENCODED PROTEIN [J].

BERGEMANN, AD ;

MA, ZW ;

JOHNSON, EM .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (12) :5673-5682

[5] Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide [J].

Bhorade, R ;

Weissleder, R ;

Nakakoshi, T ;

Moore, A ;

Tung, CH .

BIOCONJUGATE CHEMISTRY, 2000, 11 (03) :301-305

[6] NUCLEAR TRANSLOCATION OF AN EXOGENOUS FUSION PROTEIN CONTAINING HIV TAT REQUIRES UNFOLDING [J].

BONIFACI, N ;

SITIA, R ;

RUBARTELLI, A .

AIDS, 1995, 9 (09) :995-1000

[7] Characterization of novel histidine-tagged tat-peptide complexes dual-labeled with 99mTc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy [J].

Bullok, KE ;

Dyszlewski, M ;

Prior, JL ;

Pica, CM ;

Sharma, V ;

Piwnica-Worms, D .

BIOCONJUGATE CHEMISTRY, 2002, 13 (06) :1226-1237

[8] Rho-A is critical for osteoclast podosome organization, motility, and bone resorption [J].

Chellaiah, MA ;

Soga, N ;

Swanson, S ;

McAllister, S ;

Alvarez, U ;

Wang, DM ;

Dowdy, SF ;

Hruska, KA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :11993-12002

[9] Calpain and mitochondria in ischemia/reperfusion injury [J].

Chen, M ;

Won, DJ ;

Krajewski, S ;

Gottlieb, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) :29181-29186

[10] Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists [J].

Chen, YNP ;

Sharma, SK ;

Ramsey, TM ;

Jiang, L ;

Martin, MS ;

Baker, K ;

Adams, PD ;

Bair, KW ;

Kaelin, WG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4325-4329

← 1 2 3 4 5 6 7 8 9 →