Identification of a region within SEL1L protein required for tumour growth inhibition

被引：18

作者：

Cattaneo, M

Canton, C

Albertini, A

Biunno, I

机构：

[1] CNR, Inst Biomed Technol, Milan, Italy

[2] Univ Milan, CISI, Ctr Biomol Interdisciplinary Studies & Ind Appl, Milan, Italy

来源：

GENE | 2004年 / 326卷

关键词：

SEL1L deletion mutant; TPR-like SEL-1 repeats; SEL1L family;

D O I：

10.1016/j.gene.2003.10.021

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：149 / 156

页数：8

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