Protection against tick-borne encephalitis virus isolated in Japan by active and passive immunization

被引：41

作者：

Chiba, N ^{[1
]}

Osada, M ^{[1
]}

Komoro, K ^{[1
]}

Mizutani, T ^{[1
]}

Kariwa, H ^{[1
]}

Takashima, I ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Environm Vet Sci, Publ Hlth Lab, Sapporo, Hokkaido 0600818, Japan

来源：

VACCINE | 1999年 / 17卷 / 11-12期

关键词：

TBE; vaccine; passive immunization; human; mouse;

D O I：

10.1016/S0264-410X(98)00360-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to establish a firm preventive measure for tick-borne: encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TEE virus strain (Oshima 5-10) for man and mouse. Furthermore. the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum was examined in the mouse model. 80% of vaccinees seroconverted against Oshima 5-10 strain after the 2nd immunization of vaccine and the remaining 20% seroconverted after the 3rd immunization. Two persons with pre-existing anti-Japanese encephalitis virus (JEV) antibodies showed low immune responses against TEE virus. In mouse vaccination and challenge tests, efficient protection was observed in mice challenged with lethal doses of Oshima 5-10 strain as well as those observed in mice with the Western subtype and the Far Eastern subtype of TEE strains. Pre-exposure treatment with rabbit anti-TEE virus serum provided complete protection against lethal challenge with Oshima 5-10 strain. For post-exposure treatment with the antibody, significant protection was observed when mice were treated 24 h after virus challenge, whereas it was not observed 48 h after virus challenge. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1532 / 1539

页数：8

共 28 条

[1]

CLARKE DH, 1964, B WORLD HEALTH ORGAN, V31, P45

[2] TECHNIQUES FOR HEMAGGLUTINATION AND HEMAGGLUTINATION-INHIBITION WITH ARTHROPOD-BORNE VIRUSES [J].