Dual Responsive Poly(N-vinylcaprolactam) Based Degradable Microgels for Drug Delivery

被引：53

作者：

Agrawal, Garima ^{[1
]}

Agrawal, Rahul ^{[2
]}

Pich, Andrij ^{[3
,4
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Polymer & Proc Engn, Saharanpur Campus,Paper Mill Rd, Saharanpur 247001, Uttar Pradesh, India

[2] Indian Inst Technol, Dept Biochem Engn & Biotechnol, New Delhi 110016, India

[3] Rhein Westfal TH Aachen, DWI Leibniz Inst Interact Mat Res, Forckenbeckstr 50, D-52056 Aachen, Germany

[4] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, Forckenbeckstr 50, D-52056 Aachen, Germany

来源：

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | 2017年 / 34卷 / 11期

关键词：

biodegradable microgels; drug delivery; hydrazone linkages; microgels; pH-responsiveness; BIOMEDICAL APPLICATIONS; CONTROLLED-RELEASE; NANOGELS; ACID; POLY(N-ISOPROPYLACRYLAMIDE); NANOPARTICLES; ENCAPSULATION; TEMPERATURE; HYDROGELS; POLYMERS;

D O I：

10.1002/ppsc.201700132

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Poly(N-vinylcaprolactam)-based biodegradable microgels are prepared for drug delivery application via precipitation polymerization using diacetone acrylamide (DAAM) and dimethyl itaconate (IADME) as comonomers. The microgel particles are subsequently crosslinked by addition of adipic acid dihydrazide, which reacts with the ketone groups of DAAM. Itaconic acid (IA) groups are generated by the hydrolysis of IADME units inside the microgels resulting into both pH and temperature sensitive microgel particles. Volume phase transition temperature of the obtained microgels is influenced by both IA content and pH of the surrounding medium. Due to the incorporation of hydrazone linkages, the microgels show degradation under acidic conditions. These microgels can effectively encapsulate doxorubicin (DOX) as a model drug and show low DOX leakage under physiological conditions while rapid DOX release is observed at low pH. The results of the cytotoxicity assay further display that the DOX-loaded microgels exhibit effective antitumor activity against HeLa cells demonstrating their great potential as drug delivery carriers for cancer therapy.

引用

页数：9

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