Chronic response of adult rat brain tissue to implants anchored to the skull

被引:158
作者
Kim, YT [1 ]
Hitchcock, RW [1 ]
Bridge, MJ [1 ]
Tresco, PA [1 ]
机构
[1] Univ Utah, Keck Ctr Tissue Engn, Dept Bioengn, Salt Lake City, UT 84112 USA
关键词
biocompatibility; fluorescence; immunochemistry; membrane;
D O I
10.1016/j.biomaterials.2003.09.010
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Using quantitative immunohistological methods, we examined the brain tissue response to hollow fiber membranes (HFMs) that were either implanted intraparenchymally, as in a cell encapsulation application, or were attached to the skull as in a biosensor application (transcranially). We found that the reaction surrounding transcranially implanted HFMs was significantly greater than that observed with intraparenchymally implanted materials including increases in immunoreactivity against GFAP, vimentin, ED-1 labeled macrophages and microglia, and several extracellular matrix proteins including collagen, fibronectin, and laminin. In general, these markers were elevated along the entire length of transcranially implanted HFMs extending into the adjacent parenchyma up to 0.5 min from the implant interface. Intraparenchymal implants did not appear to have significant involvement of a fibroblastic component as suggested by a decreased expression of vimentin, fibronectin and collagen-type I at the implant tissue interface. The increase in tissue reactivity observed with transcranially implanted HFMs may be influenced by several mechanisms including chronic contact with the meninges and possibly motion of the device within brain tissue. Broadly speaking, our results suggest that any biomaterial, biosensor or device that is anchored to the skull and in chronic contact with meningeal tissue will have a higher level of tissue reactivity than the same material completely implanted within brain tissue. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2229 / 2237
页数:9
相关论文
共 40 条
[1]   INTERACTIONS BETWEEN MENINGEAL CELLS AND ASTROCYTES INVIVO AND INVITRO [J].
ABNET, K ;
FAWCETT, JW ;
DUNNETT, SB .
DEVELOPMENTAL BRAIN RESEARCH, 1991, 59 (02) :187-196
[2]  
Berry M, 1983, Acta Neurochir Suppl (Wien), V32, P31
[3]   Local inflammatory response around diffusion chambers containing xenografts - Nonspecific destruction of tissues and decreased local vascularization [J].
Brauker, J ;
Martinson, LA ;
Young, SK ;
Johnson, RC .
TRANSPLANTATION, 1996, 61 (12) :1671-1677
[4]   Ethanol treatment alters the ultrastructure and permeability of PAN-PVC hollow fiber cell encapsulation membranes [J].
Bridge, MJ ;
Broadhead, KW ;
Hlady, V ;
Tresco, PA .
JOURNAL OF MEMBRANE SCIENCE, 2002, 195 (01) :51-64
[5]   TISSUE-REACTIONS TO LONG-TERM ELECTRICAL-STIMULATION OF CEREBELLUM IN MONKEYS [J].
BROWN, WJ ;
BABB, TL ;
SOPER, HV ;
LIEB, JP ;
OTTINO, CA ;
CRANDALL, PH .
JOURNAL OF NEUROSURGERY, 1977, 47 (03) :366-379
[6]   TISSUE REACTION TO INTRAPERITONEAL POLYMER IMPLANTS - SPECIES-DIFFERENCE AND EFFECTS OF CORTICOID AND DOXORUBICIN [J].
CHRISTENSON, L ;
AEBISCHER, P ;
MCMILLAN, P ;
GALLETTI, PM .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1989, 23 (07) :705-718
[7]   FIBRONECTIN IMMUNOREACTIVITY IN NEURAL TRAUMA [J].
EGAN, RA ;
VIJAYAN, VK .
BRAIN RESEARCH, 1991, 568 (1-2) :330-334
[8]   The glial scar and central nervous system repair [J].
Fawcett, JW ;
Asher, RA .
BRAIN RESEARCH BULLETIN, 1999, 49 (06) :377-391
[9]   Cellular dynamics of macrophages and microglial cells in reaction to stab wounds in rat cerebral cortex [J].
Fujita, T ;
Yoshimine, T ;
Maruno, M ;
Hayakawa, T .
ACTA NEUROCHIRURGICA, 1998, 140 (03) :275-279
[10]  
GELLER HM, 1988, PROG BRAIN RES, V78, P643