Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

被引：43

作者：

Iwase, Y

Takemura, Y

Ju-ichi, M

Mukainaka, T

Ichiishi, E

Ito, C

Furukawa, H

Yano, M

Tokuda, H

Nishino, H

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[3] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan

[4] Natl Inst Fruit Tree Sci, Shizuoka 4240292, Japan

来源：

CANCER LETTERS | 2001年 / 173卷 / 02期

关键词：

flavonoid derivative; quercetin pentaallyl ether; anti-tumor promoter; two-stage carcinogenesis;

D O I：

10.1016/S0304-3835(01)00615-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To search for possible anti-tumor promoters, ten flavonoid derivatives (1-10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 109

页数：5

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