Breast cancer following diethylstilbestrol exposure in utero: insights from a tragedy

被引：19

作者：

Adami, Hans-Olov ^{[2
,3
]}

Lagiou, Pagona ^{[1
,2
]}

Trichopoulos, Dimitrios ^{[2
]}

机构：

[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2012年 / 27卷 / 01期

关键词：

Diethylstilbestrol; DES; Estrogens; In utero; Breast cancer; YOUNG-WOMEN; RISK; EPIDEMIOLOGY;

D O I：

10.1007/s10654-012-9655-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Diethylstilbestrol (DES), a powerful synthetic estrogen introduced in 1938, was prescribed to prevent pregnancy complications, but was later shown to have a series of adverse side-effects in the offspring, including cancer of the vagina. Recent evidence indicates that in utero exposure to DES is also linked to breast cancer in women over the age of 40 years. This evidence provides support to the hypothesis that in utero exposures may affect breast cancer risk in adult life.

引用

页码：1 / 3

页数：3

共 13 条

[1] BREAST-CANCER IN MOTHERS GIVEN DIETHYLSTILBESTROL IN PREGNANCY
GREENBERG, ER
BARNES, AB
RESSEGUIE, L
BARRETT, JA
BURNSIDE, S
LANZA, LL
NEFF, RK
STEVENS, M
YOUNG, RH
COLTON, T
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (22) : 1393 - 1398
[2] Cancer risk in women exposed to diethylstilbestrol in utero
Hatch, EE
Palmer, JR
Titus-Ernstoff, L
Noller, KL
Kaufman, RH
Mittendorf, R
Robboy, SJ
Hyer, M
Cowan, CM
Adam, E
Colton, T
Hartge, P
Hoover, RN
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (07): : 630 - 634
[3] ADENOCARCINOMA OF VAGINA - ASSOCIATION OF MATERNAL STILBESTROL THERAPY WITH TUMOR APPEARANCE IN YOUNG WOMEN
HERBST, AL
ULFELDER, H
POSKANZER, DC
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1971, 284 (16) : 878 - +
[4] Adverse Health Outcomes in Women Exposed In Utero to Diethylstilbestrol
Hoover, Robert N.
Hyer, Marianne
Pfeiffer, Ruth M.
Adam, Ervin
Bond, Brian
Cheville, Andrea L.
Colton, Theodore
Hartge, Patricia
Hatch, Elizabeth E.
Herbst, Arthur L.
Karlan, Beth Y.
Kaufman, Raymond
Noller, Kenneth L.
Palmer, Julie R.
Robboy, Stanley J.
Saal, Robert C.
Strohsnitter, William
Titus-Ernstoff, Linda
Troisi, Rebecca
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (14) : 1304 - 1314
[5] Causality in cancer epidemiology
Lagiou, P
Adami, HO
Trichopoulos, D
[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2005, 20 (07) : 565 - 574
[6] Risk of breast cancer in women exposed to diethylstilbestrol in utero:: preliminary results (United States)
Palmer, JR
Hatch, EE
Rosenberg, CL
Hartge, P
Kaufman, RH
Titus-Ernstoff, L
Noller, KL
Herbst, AL
Rao, RS
Troisi, R
Colton, T
Hoover, RN
[J]. CANCER CAUSES & CONTROL, 2002, 13 (08) : 753 - 758
[7] Prenatal diethylstilbestrol exposure and risk of breast cancer
Palmer, Julie R.
Wise, Lauren A.
Hatch, Elizabeth E.
Troisi, Rebecca
Titus-Ernstoff, Linda
Strohsnitter, William
Kaufman, Raymond
Herbst, Arthur L.
Noller, Kenneth L.
Hyer, Marianne
Hoover, Robert N.
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (08) : 1509 - 1514
[8] ROTHENBERGER K, 1986, P19
[9] INCREASED EXCRETION OF PREGNANEDIOL IN PREGNANCY FROM DIETHYLSTILBESTROL WITH SPECIAL REFERENCE TO THE PREVENTION OF LATE PREGNANCY ACCIDENTS
SMITH, OW
SMITH, GV
HURWITZ, D
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1946, 51 (03) : 411 - 415
[10] HYPOTHESIS - DOES BREAST-CANCER ORIGINATE INUTERO
TRICHOPOULOS, D
[J]. LANCET, 1990, 335 (8695) : 939 - 940

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