Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury

被引：32

作者：

Dittgen, Tanjew ^{[1
]}

Pitzer, Claudia ^{[1
]}

Plaas, Christian ^{[1
]}

Kirsch, Friederike ^{[1
]}

Vogt, Gerhard ^{[1
]}

Laage, Rico ^{[1
]}

Schneider, Armin ^{[1
]}

机构：

[1] SYGNIS Biosci, Heidelberg, Germany

来源：

PLOS ONE | 2012年 / 7卷 / 01期

关键词：

FUNCTIONAL RECOVERY; STEM-CELLS; REGENERATION; DISEASE; LIGAND; DEATH; MICE;

D O I：

10.1371/journal.pone.0029880

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function.

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页数：5

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