Philadelphia positive acute lymphoblastic leukaemia of childhood

被引：37

作者：

Jones, LK ^{[1
]}

Saha, V ^{[1
]}

机构：

[1] Queen Mary Univ London, Canc Res UK Childrens Canc Grp, Dept Paediat Haematol & Oncol, Barts & London Sch Med & Dent, London EC1M 6BQ, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 130卷 / 04期

关键词：

Philadelphia positive acute lymphoblastic leukaemia; childhood;

D O I：

10.1111/j.1365-2141.2005.05611.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

On current chemotherapeutic regimens, children with Philadelphia positive acute lymphoblastic leukaemia show a heterogeneous response to treatment. A few respond quickly to treatment and achieve long-term remission. Some fail to achieve remission after induction and the majority respond slowly to treatment. Relapse on treatment is common and remission is sustained in a proportion of cases only after allogeneic stem cell transplantation (allo-SCT). The use of imatinib along with conventional cytoreductive therapy, prior to allo-SCT appears to be the most promising strategy. The future lies in the molecular evaluation of response to treatment and combination targeted chemotherapy.

引用

页码：489 / 500

页数：12

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