Combinatorial 'library on bead' approach to polymeric materials with vastly enhanced chiral recognition

被引：24

作者：

Murer, P ^{[1
]}

Lewandowski, K ^{[1
]}

Svec, F ^{[1
]}

Fréchet, JMJ ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 23期

关键词：

D O I：

10.1039/a806397d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general screening method for enantiomer recognition is introduced for the rapid preparation of novel chiral stationary phases for HPLC in which libraries of mixed chiral selectors are immobilized on polymer beads and the resulting chiral phases tested in the separation of racemic targets followed by deconvolution to afford an optimized separation medium.

引用

页码：2559 / 2560

页数：2

共 15 条

[1] Ahuja S., 1997, Chiral Separations Applications and technology, V1st
[2] DIRECT LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS ON IMMOBILIZED PROTEIN STATIONARY PHASES .3. OPTICAL RESOLUTION OF A SERIES OF N-AROYL D,L-AMINO ACIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON BOVINE SERUM-ALBUMIN COVALENTLY BOUND TO SILICA
ALLENMARK, S
BOMGREN, B
BOREN, H
[J]. JOURNAL OF CHROMATOGRAPHY, 1983, 264 (01): : 63 - 68
[3] MACROCYCLIC ANTIBIOTICS AS A NEW CLASS OF CHIRAL SELECTORS FOR LIQUID-CHROMATOGRAPHY
ARMSTRONG, DW
TANG, YB
CHEN, SS
ZHOU, YW
BAGWILL, C
CHEN, JR
[J]. ANALYTICAL CHEMISTRY, 1994, 66 (09) : 1473 - 1484
[4] CYCLODEXTRIN BONDED PHASES FOR THE LIQUID-CHROMATOGRAPHIC SEPARATION OF OPTICAL, GEOMETRICAL, AND STRUCTURAL ISOMERS
ARMSTRONG, DW
DEMOND, W
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1984, 22 (09) : 411 - 415
[5] Davankov V.A., 1980, ADV CHROMATOGR, P139
[6] Lessons from the immune system: From catalysis to materials science
HsiehWilson, LC
Xiang, XD
Schultz, PG
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) : 164 - 170
[7] AFFINITY PURIFICATION OF PROTEINS USING LIGANDS DERIVED FROM PEPTIDE LIBRARIES
HUANG, PY
CARBONELL, RG
[J]. BIOTECHNOLOGY AND BIOENGINEERING, 1995, 47 (03) : 288 - 297
[8] Polar, monodisperse, reactive beads from functionalized methacrylate monomers by staged templated suspension polymerization
Lewandowski, K
Svec, F
Frechet, JMJ
[J]. CHEMISTRY OF MATERIALS, 1998, 10 (01) : 385 - 391
[9] Polymer- versus silica based separation media: Elimination of nonspecific interactions in the chiral recognition process through functional polymer design
Liu, YL
Svec, F
Frechet, JMJ
Juneau, KN
[J]. ANALYTICAL CHEMISTRY, 1997, 69 (01) : 61 - 65
[10] Okamoto Y, 1998, ANGEW CHEM INT EDIT, V37, P1020, DOI 10.1002/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO

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