A new phloroglucinol derivative from the brown alga Eisenia bicyclis:: Potential for the effective treatment of diabetic complications

被引：110

作者：

Okada, Y ^{[1
]}

Ishimaru, A ^{[1
]}

Suzuki, R ^{[1
]}

Okuyama, T ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Nat Med & Phytochem, Kiyose, Tokyo 2048588, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 01期

关键词：

D O I：

10.1021/np030323j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new phloroglucinol derivative (1) and two known compounds (2 and 3) were isolated from the brown alga Eisenia bicyclis. These isolates exhibit inhibitory activity on glycation and alpha-amylase. Their structures were determined on the basis of spectroscopic data.

引用

页码：103 / 105

页数：3

共 8 条

[1] ECKOLS, NOVEL PHLOROTANNINS WITH A DIBENZO-PARA-DIOXIN SKELETON POSSESSING INHIBITORY EFFECTS ON ALPHA-2-MACROGLOBULIN FROM THE BROWN ALGA ECKLONIA-KUROME OKAMURA [J].

FUKUYAMA, Y ;

MIURA, I ;

KINZYO, Z ;

MORI, H ;

KIDO, M ;

NAKAYAMA, Y ;

TAKAHASHI, M ;

OCHI, M .

CHEMISTRY LETTERS, 1985, (06) :739-742

[2]

HORIUCHI S, 1991, J BIOL CHEM, V266, P7329

[3]

Iwahori Yoshihiro, 1999, Natural Medicines, V53, P138

[4]

MURATA T, 2000, Patent No. 0044484

[5] Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation [J].

Nakamura, S ;

Makita, Z ;

Ishikawa, S ;

Yasumura, K ;

Fujii, W ;

Yanagisawa, K ;

Kawata, T ;

Koike, T .

DIABETES, 1997, 46 (05) :895-899

[6] Antioxidant activity of phlorotannins isolated from the brown alga Eisenia bicyclis [J].

Nakamura, T ;

Nagayama, K ;

Uchida, K ;

Tanaka, R .

FISHERIES SCIENCE, 1996, 62 (06) :923-926

[7] Two flavone C-glycosides from the style of Zea mays with glycation inhibitory activity [J].

Suzuki, R ;

Okada, Y ;

Okuyama, T .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (04) :564-565

[8] A new flavone C-glycoside from the style of Zea mays L. with glycation inhibitory activity [J].

Suzuki, R ;

Okada, Y ;

Okuyama, T .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2003, 51 (10) :1186-1188

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