The SWI/SNF complex - Chromatin and cancer

被引：476

作者：

Roberts, CWM ^{[1
]}

Orkin, SH

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrc1273

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The SWI/SNF complex is an evolutionarily conserved multi-subunit chromatin-remodelling complex, which uses the energy of ATP hydrolysis to mobilize nucleosomes and remodel chromatin. Increasing evidence supports a role for this complex in cancer development, as several subunits possess intrinsic tumour-suppressor activity or are required for the activity of other tumour-suppressor genes. For example, conditional inactivation of the Snf5 gene resulted in a highly penetrant cancer phenotype in mice. So, what are the links between the SWI/SNF complex and cancer, and what mechanisms might facilitate its involvement in oncogenesis?

引用

页码：133 / 142

页数：10

共 79 条

[1]

Adler HT, 1999, MOL CELL BIOL, V19, P7050

[2]

Amati B., 2001, BIOCHIM BIOPHYS ACTA, V1471, P135

[3] The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation [J].