Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate:: Mechanism of action and relevance to psychiatric disorders

被引：65

作者：

Perez-Neri, Ivan ^{[1
]}

Montes, Sergio ^{[1
]}

Ojeda-Lopez, Carmen ^{[1
,2
]}

Ramirez-Bermudez, Jesus ^{[2
]}

Rios, Camilo ^{[1
]}

机构：

[1] Natl Inst Neurol & Neurosurg, Dept Neurochem, Mexico City 14269, DF, Mexico

[2] Natl Inst Neurol & Neurosurg, Dept Psychiat, Mexico City 14269, DF, Mexico

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2008年 / 32卷 / 05期

关键词：

anxiety; cerebral blood flow; major depressive disorder; mood; schizophrenia;

D O I：

10.1016/j.pnpbp.2007.12.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dehydroepiandrosterone (DHEA) is synthesized in the brain and several studies have shown that this steroid is a modulator of synaptic transmission. The effect of DHEA, and its sulfate ester DHEAS, on glutamate and GABA neurotransmission has been extensively studied but some effects on other neurotransmitter systems, such as dopamine, serotonin and nitric oxide, have also been reported. This review summarizes studies showing the effect of DHEA and DHEAS on neurotransmitter systems at different levels (metabolism, release, reuptake, receptor activation), as well as the activation of voltage-gated ion channels and calcium homeostasis, showing the variety of effects that these steroids exert on those systems, allowing the discussion of its mechanisms of action and its relevance to psychiatric disorders. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：1118 / 1130

页数：13

共 142 条

[1] Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion [J].

Arlt, W ;

Callies, F ;

Koehler, I ;

van Vlijmen, JC ;

Fassnacht, M ;

Strasburger, CJ ;

Seibel, MJ ;

Huebler, D ;

Ernst, M ;

Oettel, M ;

Reincke, M ;

Schulte, HM ;

Allolio, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) :4686-4692

[2] Dehydroepiandrosterone replacement in women with adrenal insufficiency [J].

Arlt, W ;

Callies, F ;

van Vlijmen, JC ;

Koehler, I ;

Reincke, M ;

Bidlingmaier, M ;

Huebler, D ;

Oettel, M ;

Ernst, M ;

Schulte, HM ;

Allolio, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (14) :1013-1020

[3] Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings [J].

Assies, J ;

Visser, I ;

Nicolson, NA ;

Eggelte, TA ;

Wekking, EM ;

Huyser, J ;

Lieverse, R ;

Schene, AH .

PSYCHIATRY RESEARCH, 2004, 128 (02) :117-122

[4] Regional cerebral blood flow in schizophrenia and the local circuit neurons hypothesis [J].

Bachneff, SA .

SCHIZOPHRENIA BULLETIN, 1996, 22 (01) :163-182

[5] EFFECTS OF DEHYDROEPIANDROSTERONE-SULFATE ON CELLULAR CALCIUM RESPONSIVENESS AND VASCULAR CONTRACTILITY [J].

BARBAGALLO, M ;

SHAN, J ;

PANG, PKT ;

RESNICK, LM .

HYPERTENSION, 1995, 26 (06) :1065-1069

[6] Influence of neurosteroids on the development of rapid tolerance to ethanol in mice [J].

Barbosa, ADE ;

Morato, GS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 431 (02) :179-188

[7]

Bergeron R, 1996, J NEUROSCI, V16, P1193

[8] Dehydroepiandrosterone treatment of midlife dysthymia [J].

Bloch, M ;

Schmidt, PJ ;

Danaceau, MA ;

Adams, LF ;

Rubinow, DR .

BIOLOGICAL PSYCHIATRY, 1999, 45 (12) :1533-1541

[9] Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension [J].

Bonnet, S ;

Dumas-de-La-Roque, E ;

Bégueret, H ;

Marthan, R ;

Fayon, M ;

Dos Santos, P ;

Savineau, JP ;

Baulieu, EE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9488-9493

[10] Neurosteroid secretion in panic disorder [J].

Brambilla, F ;

Biggio, G ;

Pisu, MG ;

Bellodi, L ;

Perna, G ;

Bogdanovich-Djukic, V ;

Purdy, RH ;

Serra, M .

PSYCHIATRY RESEARCH, 2003, 118 (02) :107-116

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