Mechanisms controlling cell cycle exit upon terminal differentiation

被引：153

作者：

Buttitta, Laura A. ^{[1
]}

Edgar, Bruce A. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2007.10.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing. recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated.

引用

页码：697 / 704

页数：8

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