Risk Factors for Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma in the Thessaloniki Eye Study

被引:75
作者
Topouzis, Fotis [1 ]
Wilson, M. Roy [2 ,3 ]
Harris, Alon [4 ]
Founti, Panayiota [1 ]
Yu, Fei [5 ]
Anastasopoulos, Eleftherios [1 ]
Pappas, Theofanis [1 ]
Koskosas, Archimidis [1 ]
Salonikiou, Angeliki [1 ]
Coleman, Anne L. [5 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Ophthalmol, Amer Hellen Educ Progress Assoc Hosp, Sch Med, Thessaloniki 54636, Greece
[2] Univ Colorado, Sch Med, Denver, CO USA
[3] Univ Colorado, Hlth Sci Ctr, Denver, CO USA
[4] Indiana Univ Sch Med, Dept Ophthalmol, Indianapolis, IN USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Eye Epidemiol, Jules Stein Eye Inst, Los Angeles, CA 90095 USA
关键词
BODY-MASS INDEX; OCULAR HYPERTENSION; INTRAOCULAR-PRESSURE; PERFUSION-PRESSURE; REFRACTIVE ERRORS; SOUTHERN INDIA; PREVALENCE; POPULATION; TENSION; CLASSIFICATION;
D O I
10.1016/j.ajo.2011.01.032
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE: To investigate risk factors for primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) in the Thessaloniki Eye Study. DESIGN: Cross-sectional, population-based study. METHODS: Randomly selected subjects 60 years of age and older (n = 2554) participated in the Thessaloniki Eye Study. Glaucomatous damage and presence of pseudoexfoliation (PEX) were defined according to specific criteria. Open-angle glaucoma (OAG) subjects were compared with nonglaucoma subjects (controls), POAG subjects were compared with controls without PEX, and PEXG subjects were compared with controls with PEX for demographic, lifestyle, ophthalmic, and systemic factors. Factors with P <.2 in the univariate analysis were retained for multivariate analyses. RESULTS: In multivariate analysis restricted to persons who participated in clinic visits and who had at least 1 phakic eye (n = 2078), intraocular pressure (odds ratio [OR], 1.21 per 1 mm Hg; P <.001), PEX (OR, 2.81; P <.001), history of coronary artery bypass or vascular surgery (OR, 1.95; P = .017), and moderate-to-high myopia 3 diopters; OR, 2.40; P = .009) were associated with higher odds for OAC;. In analysis including all clinic visits (n = 2261), age became significantly associated (OR, 1.05; P = .004). In multivariate analysis for POAG (n = 1840), associations were found for age (OR, 1.04 per year; P = .048), IOP (OR, 1.19 per 1 mm Hg; P <.001), history of coronary artery bypass or vascular surgery (OR, 2.09; P = .01), and history of diabetes treated with insulin (OR, 3.05; P = .045). In multivariate analysis for PEXG (n = 238), the latter was associated with increased IOP (OR, 1.25 per 1 mm Hg; P <.001). CONCLUSIONS: KV was the only factor associated with both POAG and PEXG, whereas moderate-to-high myopia showed borderline significance in both. Vascular systemic diseases and their treatment were associated only with POAG. The implications of these differences for the pathogenesis between the 2 common types of OAG should be explored further. (Am J Ophthalmol 2011;152:219-228. 2011 by Elsevier Inc. All rights reserved.)
引用
收藏
页码:219 / 228
页数:10
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