Formation of chromosome aberrations: insights from FISH

被引：39

作者：

Natarajan, A ^{[1
]}

Boei, JJWA ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Toxicogenet, NL-2333 AL Leiden, Netherlands

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2003年 / 544卷 / 2-3期

关键词：

chromosome aberrations; fluorescence in situ hybridization (FISH); DNA;

D O I：

10.1016/j.mrrev.2003.09.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Most of the mutagettic and carcinogenic agents induce chromosome aberrations in vivo and in vitro. Conventional solid staining (such as Giemsa) has been employed to evaluate the frequencies and types of spontaneous and induced chromosomal aberrations. Recently, molecular cytogenetic techniques such as fluorescence in situ hybridization (FISH) using chromosome specific or chromosome region-specific DNA libraries have become available, which have increased the resolution of the detection of aberrations. This has lead to a better understanding on the mechanisms of formation of chromosome aberrations, especially following treatment with ionizing radiation. The present paper reviews briefly the results obtained using FISH technique both from basic and applied studies. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：299 / 304

页数：6

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