Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

被引：13

作者：

Chretien, Aline ^{[1
]}

Delaive, Edouard ^{[1
]}

Dieu, Marc ^{[1
]}

Demazy, Catherine ^{[1
]}

Ninane, Noelle ^{[1
]}

Raes, Martine ^{[1
]}

Toussaint, Olivier ^{[1
]}

机构：

[1] Univ Namur FUNDP, Unit Res Cellular Biol, B-5000 Namur, Belgium

来源：

EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 04期

关键词：

H2O2; senescence; fibroblasts; proteomics; membrane; annexin;

D O I：

10.1016/j.exger.2008.01.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：353 / 359

页数：7

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