Drosophila melted modulates FOXO and TOR activity

被引：101

作者：

Teleman, AA ^{[1
]}

Chen, YW ^{[1
]}

Cohen, SM ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 02期

关键词：

D O I：

10.1016/j.devcel.2005.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The insulin/PI3K signaling pathway controls both tissue growth and metabolism. Here, we identify Melted as a new modulator of this pathway in Drosophila. Melted interacts with both Tsc1 and FOXO and can recruit these proteins to the cell membrane. We provide evidence that in the melted mutant, TOR activity is reduced and FOXO is activated. The melted mutant condition mimics the effects of nutrient deprivation in a normal animal, producing an animal with 40% less fat than normal.

引用

收藏

页码：271 / 281

页数：11

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