Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells

被引:20
作者
Katayama, H
Ota, T
Morita, K
Terada, Y
Suzuki, F
Katoh, O
Tatsuka, M [1 ]
机构
[1] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Regulatory Radiobiol, Hiroshima 7348553, Japan
[2] Hiroshima Univ, Fac Sci, Grad Dept Gene Sci, Higashihiroshima 7398526, Japan
[3] Kanazawa Med Univ, Dept Pathol, Ishikawa 9200265, Japan
[4] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Environm & Mutat, Hiroshima 7348553, Japan
关键词
polyploidization; mitosis; cytokinesis; midbody; serine/threonine kinase; STK-1;
D O I
10.1016/S0378-1119(98)00522-8
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The rat AIM-1 gene encoding an Aurora- and Ipl1-like midbody-associated protein serine/threonine kinase has a mitotic regulator function playing a key role in the onset of cytokinesis during mitosis. This report presents a cDNA sequence and megakaryocytic differentiaion-dependent expression profile of the human AIM-1 gene. The nucleotide sequences of the human AIM-1 were identified from cDNAs of three cell lines, including cervical carcinoma HeLa cells, colorectal tumor SW480 cells, and normal human diploid skin fibroblast NHDF cells, and no mutation was found. The expression levels of AIM-1 transcript were markedly reduced during differentiation into megakaryocytic cell lineage in human leukemia cells induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), suggesting that the downregulation of AIM-1 contributes to the differentiation by repeated duplication of DNA without cytokinesis (endomitosis). (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 7
页数:7
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