Human gut microbiome viewed across age and geography

被引：5610

作者：

Yatsunenko, Tanya ^{[1
]}

Rey, Federico E. ^{[1
]}

Manary, Mark J. ^{[2
,3
]}

Trehan, Indi ^{[2
,4
]}

Dominguez-Bello, Maria Gloria ^{[5
]}

Contreras, Monica ^{[6
]}

Magris, Magda ^{[7
]}

Hidalgo, Glida ^{[7
]}

Baldassano, Robert N. ^{[8
]}

Anokhin, Andrey P. ^{[9
]}

Heath, Andrew C. ^{[9
]}

Warner, Barbara ^{[2
]}

Reeder, Jens ^{[10
]}

Kuczynski, Justin ^{[10
]}

Caporaso, J. Gregory ^{[11
]}

Lozupone, Catherine A. ^{[10
]}

Lauber, Christian ^{[10
]}

Clemente, Jose Carlos ^{[10
]}

Knights, Dan ^{[10
]}

Knight, Rob ^{[10
,12
]}

Gordon, Jeffrey I. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA

[2] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[3] Univ Malawi, Dept Community Hlth, Coll Med, Blantyre, Malawi

[4] Univ Malawi, Dept Paediat & Child Hlth, Coll Med, Blantyre, Malawi

[5] Univ Puerto Rico, Dept Biol, Rio Piedras, PR 00931 USA

[6] Venezuelan Inst Sci Res IVIC, Altos De Pipe, Venezuela

[7] Amazon Ctr Res & Control Trop Dis CAICET, Amazonas, Venezuela

[8] Childrens Hosp Philadelphia, Div Gastroenterol & Nutr, Philadelphia, PA 19104 USA

[9] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[10] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[11] No Arizona Univ, Dept Comp Sci, Flagstaff, AZ 86001 USA

[12] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

NATURE | 2012年 / 486卷 / 7402期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

FREE AMINO-ACIDS; INTESTINAL MICROBIOTA; BACTERIAL COMMUNITIES; HUMAN INFANT; NORMAL MEN; UREA; NITROGEN; CLUSTER; VALIDATION; PROTEIN;

D O I：

10.1038/nature11053

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono-and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.

引用

页码：222 / +

页数：7

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