Role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion

被引：47

作者：

Bai, Longchuan ^{[1
]}

Merchant, Juanita L. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 30期

关键词：

histone deacetylase inhibitor; butyrate; matrix metalloproteinase-13; beta-catenin;

D O I：

10.1016/j.febslet.2007.11.072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A thorough understanding of histone acetyltransferase CBP/p300-mediated regulation of gene expression and cell growth is essential to identify mechanisms relevant to the development of histone deacetylase (HDAC) inhibitor-based preventive and therapeutic strategies. We found that knockdown of CBP/p300 interacting coactivator with glutamic acid/aspartic acid-rich tail 2 (CITED2) increased colon cancer cell invasiveness in vitro. Gene expression pro. ling revealed that CITED2 knockdown induced matrix metalloproteinase-13 (MMP-13) gene expression in colon cancer cells. Butyrate, a naturally occurring HDAC inhibitor, induced CITED2 expression and downregulated MMP-13 expression in RKO cells. Additionally, ectopic expression of CITED2 arrested RKO cell growth. Thus, CITED2 regulates colon cancer invasion and might be a target for HDAC inhibitor-based intervention of colon cancer. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：5904 / 5910

页数：7

共 35 条

[1] In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates [J].

Aparicio, A ;

Gardner, A ;

Tu, Y ;

Savage, A ;

Berenson, J ;

Lichtenstein, A .

LEUKEMIA, 1998, 12 (02) :220-229

[2] Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells [J].

Bai, LC ;

Merchant, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :30725-30733

[3] Recruitment of ataxia-telangiectasia mutated to the p21waf1 promoter by ZBP-89 plays a role in mucosal protection [J].

Bai, Longchuan ;

Kao, John Y. ;

Law, David J. ;

Merchant, Juanita L. .

GASTROENTEROLOGY, 2006, 131 (03) :841-852

[4] Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator [J].

Bamforth, SD ;

Bragança, J ;

Eloranta, JJ ;

Murdoch, JN ;

Marques, FIR ;

Kranc, KR ;

Farza, H ;

Henderson, DJ ;

Hurst, HC ;

Bhattacharya, S .

NATURE GENETICS, 2001, 29 (04) :469-474

[5] Folic acid prevents exencephaly in Cited2 deficient mice [J].

Barbera, JPM ;

Rodriguez, TA ;

Greene, NDE ;

Weninger, WJ ;

Simeone, A ;

Copp, AJ ;

Beddington, RSP ;

Dunwoodie, S .

HUMAN MOLECULAR GENETICS, 2002, 11 (03) :283-293

[6] RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2 [J].

Batsché, E ;

Muchardt, C ;

Behrens, J ;

Hurst, HC ;

Crémisi, C .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (07) :3647-3658

[7] Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 [J].

Bhattacharya, S ;

Michels, CL ;

Leung, MK ;

Arany, ZP ;

Kung, AL ;

Livingston, DM .

GENES & DEVELOPMENT, 1999, 13 (01) :64-75

[8] Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 [J].

Bragança, J ;

Eloranta, JJ ;

Bamforth, SD ;

Ibbitt, JC ;

Hurst, HC ;

Bhattacharya, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (18) :16021-16029

[9] Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 [J].

Bragança, J ;

Swingler, T ;

Marques, FIR ;

Jones, T ;

Eloranta, JJ ;

Hurst, HC ;

Shioda, T ;

Bhattacharya, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) :8559-8565

[10] Cited2 modulates TGF-β-mediated upregulation of MMP9 [J].

Chou, Y-T ;

Wang, H. ;

Chen, Y. ;

Danielpour, D. ;

Yang, Y-C .

ONCOGENE, 2006, 25 (40) :5547-5560

← 1 2 3 4 →