Pharmacological manipulation of Bcl-2 family members to control cell death

被引：109

作者：

Letai, A ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 10期

关键词：

D O I：

10.1172/JCI26250

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.

引用

页码：2648 / 2655

页数：8

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