RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes

被引:179
作者
Sevin, Emeric W. [1 ]
Barloy-Hubler, Frederique [1 ,2 ]
机构
[1] Univ Rennes 1, CNRS, UMR Genet & Dev 6061, IFR 140, F-35043 Rennes, France
[2] Univ Rennes 1, Grp DUALS, CNRS, UMR Interact Cellulaires & Mol 6026,IFR 140, F-35042 Rennes, France
关键词
D O I
10.1186/gb-2007-8-8-r155
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Toxin/antitoxin (TA) systems, viewed as essential regulators of growth arrest and programmed cell death, are widespread among prokaryotes, but remain sparsely annotated. We present RASTA-Bacteria, an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic genomes, whether they are annotated open reading frames or not. The tool successfully confirmed all reported TA systems, and spotted new putative loci upon screening of sequenced genomes. RASTA-Bacteria is publicly available at http://genoweb.univ-rennes1.fr/duals/ RASTA-Bacteria.
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页数:14
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