Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates

被引：49

作者：

Callaway, EC

Zhang, YS

Chew, W

Chow, HHS

机构：

[1] Univ Arizona, Coll Med, Arizona Canc Ctr, Tucson, AZ 85724 USA

[2] Univ Arizona, Coll Med, Dept Med, Tucson, AZ 85724 USA

来源：

CANCER LETTERS | 2004年 / 204卷 / 01期

关键词：

isothiocyanate; isothiocyanate transport; multidrug resistance associated protein-1; P-glycoprotein-1; allyl isothiocyanate; benzyl isothiocyanate; phenethyl isothiocyanate;

D O I：

10.1016/j.canlet.2003.09.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many dietary isothiocyanates (ITCs) are potent anticarcinogenic agents. ITCs rapidly accumulate to high concentrations in cells as a result of conjugation with intracellular thiols, especially glutathione (GSH). The anticarcinogenic activity of ITCs depends on, at least partly, their accumulation in cells. We report that three major anticarcinogenic ITCs, including allyl-ITC, benzyl-ITC, and phenethyl-ITC, were rapidly exported, upon accumulation in cells, mainly in the forms of GSH- and cysteinylglycine-conjugates, apparently involving MRP-1 and Pgp-1. These findings are consistent with our previous results regarding cellular export of another anticarcinogenic ITC, sulforaphane, and suggest a common cellular response to ITCs. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：23 / 31

页数：9

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