A functional model related to cytochrome c oxidase and its electrocatalytic four-electron reduction of O-2

被引：178

作者：

Collman, JP

Fu, L

Herrmann, PC

Zhang, XM

机构：

[1] Department of Chemistry, Stanford University, Stanford

来源：

SCIENCE | 1997年 / 275卷 / 5302期

关键词：

D O I：

10.1126/science.275.5302.949

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A cytochrome c oxidase model that consists of a cobalt(II) porphyrin with a copper(I) triazacyclononane macrocycle fastened on the distal face and an imidazole covalently attached to the proximal face has been synthesized and characterized. Redox titrations with molecular oxygen (O-2) and cobaltocene were carried out, and O-2 was found to bind irreversibly in a 1:1 ratio to the model compound. This O-2 adduct (a bridged peroxide) can be fully reduced to the deoxygenated form with four equivalents of cobaltocene. The model compound was adsorbed on an edge-plane graphite electrode, and rotating ring-disk voltammetry was used to monitor the electrocatalytic reduction of O-2. Four-electron reduction of O-2 was observed at physiological pH.

引用

页码：949 / 951

页数：3

共 20 条

[1] OXYGEN ACTIVATION AND THE CONSERVATION OF ENERGY IN CELL RESPIRATION
BABCOCK, GT
WIKSTROM, M
[J]. NATURE, 1992, 356 (6367) : 301 - 309
[2] BLACKMORE RS, 1991, J BIOL CHEM, V266, P19245
[3] STRUCTURE AND FUNCTION OF CYTOCHROME-C-OXIDASE
CAPALDI, RA
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 : 569 - 596
[4] CYTOCHROME-C OXIDASE - UNDERSTANDING NATURES DESIGN OF A PROTON PUMP
CHAN, SI
LI, PM
[J]. BIOCHEMISTRY, 1990, 29 (01) : 1 - 12
[5] ELECTROCATALYTIC REDUCTION OF DIOXYGEN TO WATER BY IRIDIUM PORPHYRINS ADSORBED ON EDGE PLANE GRAPHITE-ELECTRODES
COLLMAN, JP
CHNG, LL
TYVOLL, DA
[J]. INORGANIC CHEMISTRY, 1995, 34 (06) : 1311 - 1324
[6] CONGRUENT MULTIPLE MICHAEL ADDITION FOR THE SYNTHESIS OF BIOMIMETIC HEME ANALOGS
COLLMAN, JP
ZHANG, XM
HERRMANN, PC
UFFELMAN, ES
BOITREL, B
STRAUMANIS, A
BRAUMAN, JI
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) : 2681 - 2682
[7] MOLECULAR CATALYSTS FOR MULTIELECTRON REDOX REACTIONS OF SMALL MOLECULES - THE COFACIAL METALLODIPORPHYRIN APPROACH
COLLMAN, JP
WAGENKNECHT, PS
HUTCHISON, JE
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (15-16): : 1537 - 1554
[8] COLLMAN JP, UNPUB
[9] STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF CYTOCHROME-C-OXIDASE FROM PARACOCCUS-DENITRIFICANS
IWATA, S
OSTERMEIER, C
LUDWIG, B
MICHEL, H
[J]. NATURE, 1995, 376 (6542) : 660 - 669
[10] Jameson GB, 1996, METAL-CONTAINING POLYMERIC MATERIALS, P421

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