Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin

被引：113

作者：

Erwin, JL

DaSilva, LM

Bavari, S

Little, SF

Friedlander, AM

Chanh, TC

机构：

[1] USA Headquarters, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA

[2] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA

[3] USA, Div Toxicol, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA

[4] USA, Div Bacteriol, Med Res Inst Infect Dis, Ft Detrick, Frederick, MD 21702 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 02期

关键词：

D O I：

10.1128/IAI.69.2.1175-1177.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.

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页码：1175 / 1177

页数：3

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