Interaction between HSP73 and HLA-DRB1*0401 - Implications for the development of rheumatoid arthritis

被引：6

作者：

Auger, I ^{[1
]}

Roudier, J ^{[1
]}

机构：

[1] Fac Med, INSERM, U 639, F-13005 Marseille, France

来源：

IMMUNOLOGIC RESEARCH | 2005年 / 31卷 / 03期

关键词：

rheumatoid arthritis; HLA-DR; HSP70; alleles; endoplasmic reticulum; antigen;

D O I：

10.1385/IR:31:3:261

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The amino acid motif QKRAA on HLA-DRB1*0401 carries susceptibility to develop rheumatoid arthritis through unknown mechanisms. We identified the original functions of this motif. In B-cells. HSP73, the constitutive 70-kDa heat-shock protein (HSP), associates with HLA-DRB1*0401. This interaction causes abnormal trafficking, of HLA-DRB1*0401. Indeed, HSP73 targets HLA-DRB1*0401 from endoplasmic reticulum to lysosomes bypassing the normal route through the Golgi apparatus and endosomes. In this article, we propose mechanisms to explain how 70-kDa HSPs might contribute to rheumatoid arthritis.

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页码：261 / 266

页数：6

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