Nitric oxide and HSP70 proteins during normal pregnancy, gestosis, and preclinical gestosis

被引：6

作者：

Bloshchinskaya, IA ^{[1
]}

Davidovich, IM ^{[1
]}

机构：

[1] Far Eastern State Univ, Khabarovsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 03期

关键词：

pregnancy; gestosis; nitric oxide; stress proteins;

D O I：

10.1023/A:1024124728672

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

We measured the content of NO metabolites in blood plasma and urine and concentration of HSP70 proteins in the plasma and leukocytes from 126 women with normal pregnancy, gestosis, and preclinical gestosis. In women with gestosis accompanied by NO deficiency the concentration of HSP70 proteins in the plasma increased more significantly than in leukocytes. These changes are an important marker of endothelial dysfunction and reflect the severity of cell damage during this disorder. The decrease in excretion of NO in the urine and increase in HSP70 protein content in leukocytes and plasma characterize endothelial dysfunction in women with preclinical gestosis.

引用

页码：241 / 243

页数：3

共 8 条

[1]

The heat shock response inhibits NF-κB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain [J].