Stress management: MHC class I and class I-like molecules as reporters of cellular stress

被引：96

作者：

Gleimer, M

Parham, P ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Program Immunol, Stanford, CA 94305 USA

来源：

IMMUNITY | 2003年 / 19卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(03)00272-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.

引用

页码：469 / 477

页数：9

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