ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL

被引：86

作者：

Kong, SE

Banks, CAS

Shilatifard, A

Conaway, JW

Conaway, RC ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

[2] St Louis Univ, Hlth Sci Ctr, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[3] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA

[4] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 29期

关键词：

elongation; mRNA synthesis; transcription; transcription factor;

D O I：

10.1073/pnas.0503017102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase 11 transcription.

引用

页码：10094 / 10098

页数：5

共 22 条

[1] AN RNA POLYMERASE-II TRANSCRIPTION FACTOR SHARES FUNCTIONAL-PROPERTIES WITH ESCHERICHIA-COLI SIGMA-70 [J].